Adipose tissue and serum CCDC80 in obesity and its association with related metabolic disease

Coiled-coil domain-containing 80 (CCDC80) is an adipocyte-secreted protein that modulates glucose homeostasis in response to diet-induced obesity in mice. The objective of this study is to analyze the link between human CCDC80 and obesity. CCDC80 protein expression was assessed in paired visceral (V...

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Published in:Molecular medicine (Cambridge, Mass.) Mass.), 2017-01, Vol.23 (1), p.225-234
Main Authors: Osorio-Conles, O, Guitart, M, Moreno-Navarrete, J M, Escoté, X, Duran, X, Fernandez-Real, J M, Gomez-Foix, A M, Fernández-Veledo, S, Vendrell, J
Format: Article
Language:English
Subjects:
Adipocytes
Adipose Tissue - metabolism
Adult
Aged
Antibodies
Body fat
Body mass index
Cell Line
Cholesterol
Female
Gene expression
Glucose
Glycoproteins - metabolism
Hospitals
Humans
Insulin resistance
Intercellular Signaling Peptides and Proteins - metabolism
Laboratories
Liver diseases
Male
Metabolism
Middle Aged
Obesity
Obesity - metabolism
Proteins
Triglycerides
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Summary:Coiled-coil domain-containing 80 (CCDC80) is an adipocyte-secreted protein that modulates glucose homeostasis in response to diet-induced obesity in mice. The objective of this study is to analyze the link between human CCDC80 and obesity. CCDC80 protein expression was assessed in paired visceral (VAT) and subcutaneous (SAT) adipose tissue from 10 subjects (BMI range 22.4-38.8 kg/m ). Circulating CCDC80 levels were quantified in serum samples from two independent cross-sectional cohorts comprising 33 lean and 15 obese (cohort 1) and 32 morbid obese (cohort 2) male subjects. Insulin sensitivity, insulin secretion and blood neutrophil count were quantified in serum samples from both cohorts. Additionally, circulating free IGF-1 levels and oral glucose tolerance tests (OGTT) were assessed in cohort 1 whereas C-reactive protein levels and degree of atherosclerosis and hepatic steatosis were studied in cohort 2. In lean subjects, total CCDC80 protein content assessed by immunoblotting was lower in VAT than in SAT. In obese patients, CCDC80 was increased in VAT (
ISSN:1076-1551
1528-3658
DOI:10.2119/molmed.2017.00067