A review on tumor immunology

The ability of immune system to detect and destroy the altered/abnormal cells may inhibit the development of various cancers. The immune system had been proposed as a tactic in sustaining nonneoplastic state and also for the development of immunotherapy against cancer. Although the immune system exe...

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Published in:Journal of orofacial sciences 2017-01, Vol.9 (1), p.7-15
Main Authors: Kaja, Sri, Kiran, S. V N, Kattapagari, Kiran, Chitturi, Ravi, Chowdary, S, Reddy, Baddam
Format: Article
Language:English
Subjects:
Cancer
Cancer treatment
immune escape
Immune response
immunoediting
immunology
immunosurveillance
Immunotherapy
tumor
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description The ability of immune system to detect and destroy the altered/abnormal cells may inhibit the development of various cancers. The immune system had been proposed as a tactic in sustaining nonneoplastic state and also for the development of immunotherapy against cancer. Although the immune system exerts a protective role, under certain circumstances, it could be damaging in terms of modulating the oncogenic process. The failure of host's immunological responses against tumor growth and dissemination implicated that both immunologic and nonimmunologic factors may work together to affect tumorigenesis. Hence, understanding the aspects pertaining to tumor immunology which deals with the complex interactions between the host's immune system and neoplasm is essential. The current review focuses on the aspects concerned with tumor immunology, steps involved, and cancer immunotherapy as a probable therapeutic tool.
doi_str_mv 10.4103/0975-8844.207949
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subjects Cancer
Cancer treatment
immune escape
Immune response
immunoediting
immunology
immunosurveillance
Immunotherapy
tumor
title A review on tumor immunology
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