The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy

The development of head and neck squamous cell carcinoma (HNSCC) is a multi-step process, and its survival depends on a complex tumor ecosystem, which not only promotes tumor growth but also helps to protect tumor cells from immune surveillance. With the advances of existing technologies and emergin...

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Bibliographic Details
Published in:Molecular cancer 2023-04, Vol.22 (1), p.68-68, Article 68
Main Authors: Gong, Yingying, Bao, Lisha, Xu, Tong, Yi, Xiaofen, Chen, Jinming, Wang, Shanshan, Pan, Zongfu, Huang, Ping, Ge, Minghua
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
Apoptosis
B cells
Cancer therapies
Carcinoma, Squamous Cell - pathology
Ecological therapy
Ecosystem
Ecosystem components
Ecosystems
Fibroblasts
Genotype & phenotype
Head & neck cancer
Head and neck carcinoma
Head and Neck Neoplasms - therapy
Head and neck squamous cell carcinoma
Human papillomavirus
Humans
Immunosurveillance
Kinases
Lymphocytes
Medical prognosis
Metastasis
MicroRNAs
Protection and preservation
Relaxation Therapy
Review
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - therapy
Stem cells
Tumor cells
Tumor ecosystem
Tumorigenesis
Tumors
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Summary:The development of head and neck squamous cell carcinoma (HNSCC) is a multi-step process, and its survival depends on a complex tumor ecosystem, which not only promotes tumor growth but also helps to protect tumor cells from immune surveillance. With the advances of existing technologies and emerging models for ecosystem research, the evidence for cell-cell interplay is increasing. Herein, we discuss the recent advances in understanding the interaction between tumor cells, the major components of the HNSCC tumor ecosystem, and summarize the mechanisms of how biological and abiotic factors affect the tumor ecosystem. In addition, we review the emerging ecological treatment strategy for HNSCC based on existing studies.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-023-01769-z