Epigenetic markers associated with schistosomiasis

It is important to consider the use of the epigenome as source of complementary data for genome knowledge, which is suitable for the diagnosis of schistosomiasis. Usually, a laboratory diagnosis of schistosomiasis is performed by means of . Egg detection in the stool or urine by microscopy remains w...

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Bibliographic Details
Published in:Helminthologia 2021-03, Vol.58 (1), p.28-40
Main Authors: Gomes Assenço, R. A., Alves Mota, E., De Oliveira, V. F., De Castro Borges, W., Guerra-Sá, R.
Format: Article
Language:English
Subjects:
Appraisals
Biomarkers
Diagnosis
DNA methylation
epigenetic markers
Epigenetics
Genomes
Health services
histone modification
Immunology
Microscopy
Minireview
miRNAs
Ova
Schistosomiasis
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Summary:It is important to consider the use of the epigenome as source of complementary data for genome knowledge, which is suitable for the diagnosis of schistosomiasis. Usually, a laboratory diagnosis of schistosomiasis is performed by means of . Egg detection in the stool or urine by microscopy remains with limited sensitivity; . Immunological screening, in which positivity persists after treatment, and . Molecular appraisals prevail over the disadvantages of the currently used methods. In this sense, molecular methodologies are being developed based on epigenetic biomarkers, aiming to improve the diagnosis of the disease and clinical treatment as early as possible to prevent the occurrence of serious liver damage.
ISSN:0440-6605
1336-9083
1336-9083
DOI:10.2478/helm-2021-0009