Nanomedicine for Ischemic Stroke

Stroke is a severe brain disease leading to disability and death. Ischemic stroke dominates in stroke cases, and there are no effective therapies in clinic, partly due to the challenges in delivering therapeutics to ischemic sites in the brain. This review is focused on the current knowledge of path...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-10, Vol.21 (20), p.7600
Main Authors: Dong, Xinyue, Gao, Jin, Su, Yujie, Wang, Zhenjia
Format: Article
Language:English
Subjects:
Adenosine
Animals
Apoptosis
Blood-brain barrier
Brain damage
Brain Ischemia - diagnostic imaging
Brain Ischemia - drug therapy
brain targeting
Chemokines
Cytokines
Drug Delivery Systems - methods
Endothelium
Homeostasis
Humans
Immune system
Inflammation
Ischemia
ischemic stroke
Kinases
Leukocytes (neutrophilic)
Nanomedicine - methods
nanoparticle-based drug delivery
Nanoparticles
Nanotechnology
Neuroimaging
Neutrophils
Nitric oxide
Oxidative stress
Pathogenesis
Pathology
Permeability
Proteins
Review
Stroke
Stroke - diagnostic imaging
Stroke - drug therapy
Tumor necrosis factor-TNF
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Summary:Stroke is a severe brain disease leading to disability and death. Ischemic stroke dominates in stroke cases, and there are no effective therapies in clinic, partly due to the challenges in delivering therapeutics to ischemic sites in the brain. This review is focused on the current knowledge of pathogenesis in ischemic stroke, and its potential therapies and diagnosis. Furthermore, we present recent advances in developments of nanoparticle-based therapeutics for improved treatment of ischemic stroke using polymeric NPs, liposomes and cell-derived nanovesicles. We also address several critical questions in ischemic stroke, such as understanding how nanoparticles cross the blood brain barrier and developing in vivo imaging technologies to address this critical question. Finally, we discuss new opportunities in developing novel therapeutics by targeting activated brain endothelium and inflammatory neutrophils to improve the current therapies for ischemic stroke.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21207600