Dietary Olive Oil Intake Improves Running Endurance with Intramuscular Triacylglycerol Accumulation in Mice

Olive oil is a functional food shown to have a variety of bioactive effects. Therefore, we expect it to be a novel functional food with an exercise-mimetic effect on skeletal muscles. This study aimed to investigate the effect of olive oil on the endurance capacity and muscle metabolism in mice. Mic...

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Bibliographic Details
Published in:Nutrients 2021-04, Vol.13 (4), p.1164
Main Authors: Komiya, Yusuke, Sugiyama, Makoto, Ochiai, Masaru, Osawa, Nanako, Adachi, Yuto, Iseki, Shugo, Arihara, Keizo
Format: Article
Language:English
Subjects:
Accumulation
DGAT1
Diet
Dietary intake
Diglycerides
Edible oils
Endurance capacity
Fatty acids
Fitness equipment
Functional foods & nutraceuticals
Gastrocnemius muscle
Gene expression
Glucose
IMTG
Insulin
Lipid metabolism
Lipids
Metabolic disorders
Metabolism
Mitochondria
Muscles
Muscular function
Musculoskeletal system
Novel foods
Nutrition research
Oils & fats
Olive oil
Plasma
Running
Skeletal muscle
Soybean oil
Soybeans
Treadmills
Triglycerides
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Summary:Olive oil is a functional food shown to have a variety of bioactive effects. Therefore, we expect it to be a novel functional food with an exercise-mimetic effect on skeletal muscles. This study aimed to investigate the effect of olive oil on the endurance capacity and muscle metabolism in mice. Mice fed a 7% ( / ) olive oil diet for eight weeks showed improved treadmill running endurance and increased intramuscular triacylglycerol (IMTG) accumulation in the gastrocnemius muscle compared to soybean oil diet-fed controls. The increase in running endurance with olive oil intake was independent of the muscle fiber type. To elucidate underlying the mechanism of elevated IMTG levels, we examined the expression levels of the genes related to lipid metabolism. We found that the expression of diacylglycerol O-acyltransferase1 (DGAT1) was significantly upregulated in the muscle of olive oil diet-fed mice. In addition, the olive oil diet-fed mice showed no metabolic impairment or differences in growth profiles compared to the controls. These results suggest that dietary olive oil intake affects muscle metabolism and muscle endurance by increasing energy accumulation.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13041164