Role of alarmin cytokines and microRNAs in the host-schistosome interaction [version 1; peer review: 3 approved]

Schistosomiasis is a serious but neglected tropical infectious disease, afflicting more than 240 million people in 78 countries. Lack of an effective vaccine and obscuring disease mechanism could be the main hurdles to effectively control and eradicate this disease. A better understanding of the hos...

Full description

Saved in:
Bibliographic Details
Published in:F1000 research 2018, Vol.7, p.1571
Main Authors: He, Xing, Pan, Weiqing
Format: Article
Language:English
Subjects:
Alarmins - immunology
Alarmins - physiology
Animals
Cytokines
Eggs
Gene expression
Host-Pathogen Interactions
Humans
Infections
Infectious diseases
MicroRNAs
MicroRNAs - physiology
miRNA
Mortality
Parasites
Pathology
Review
Rodents
Roles
Schistosoma
Schistosomiasis
Schistosomiasis - immunology
Tropical diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Schistosomiasis is a serious but neglected tropical infectious disease, afflicting more than 240 million people in 78 countries. Lack of an effective vaccine and obscuring disease mechanism could be the main hurdles to effectively control and eradicate this disease. A better understanding of the host-schistosome interaction is the key to clearing these hurdles. Recently, accumulating evidence shows that alarmin cytokines and microRNAs (miRNAs) are crucial regulators in the host-schistosome interaction. Alarmin cytokines are proven to be potent mechanisms driving type 2 immunity, which is the central disease mechanism of schistosomiasis. MiRNA deregulation is a hallmark of a variety of human diseases, including schistosomiasis. In this review, we summarize the research advances on the role of alarmin cytokines and miRNAs in the host-schistosome interaction.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.15695.1