Mechanism-Dependent Selectivity: Fluorocyclization of Unsaturated Carboxylic Acids or Alcohols by Hypervalent Iodine

To understand the unprecedented difference between and selectivity in hypervalent iodine (III) promoted fluorocyclization of unsaturated carboxylic acids or alcohols by difluoroiodotoluene, density functional theory (DFT) studies have been performed to systematically compare both the previous propos...

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Bibliographic Details
Published in:Frontiers in chemistry 2022-05, Vol.10, p.897828-897828
Main Authors: Su, Jiaqi, Shu, Siwei, Li, Yinwu, Chen, Yong, Dong, Jinxiang, Liu, Yan, Fang, Yanxiong, Ke, Zhuofeng
Format: Article
Language:English
Subjects:
5-oxo
6-endo
Chemistry
cyclization
fluorination
hypervalent iodine
mechanism
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Summary:To understand the unprecedented difference between and selectivity in hypervalent iodine (III) promoted fluorocyclization of unsaturated carboxylic acids or alcohols by difluoroiodotoluene, density functional theory (DFT) studies have been performed to systematically compare both the previous proposed "fluorination first and cyclization later" mechanism and the alternative "cyclization first and fluorination later" mechanism. Our results revealed that the selectivity is mechanism-dependent. The unsaturated alcohol prefers the fluorination first and the cyclization later pathway, leading to the experimentally observed ether product. In contrast, the unsaturated carboxylic acid plausibly undergoes the cyclization first and the fluorination later to the experimentally observed lactone product. The p property of the functional group of the substrate is found to play a key role in determining the reaction mechanism. The provided insights into the mechanism-dependent selectivity should help advance the development of fluorocyclization reactions with hypervalent iodine reagents.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2022.897828