Serum Osteocalcin Is Associated with Inflammatory Factors in Metabolic Syndrome: A Population-Based Study in Chinese Males

Osteocalcin (OCN) was potentially associated with inflammatory factors, so we explored the metabolic role in this association in general population. Our findings suggest that OCN was positively associated with IgG while inversely associated with C3, both of which were probably mediated by obesity. M...

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Bibliographic Details
Published in:Mediators of Inflammation 2015-01, Vol.2015 (2015), p.587-594-360
Main Authors: Zhang, Haiying, Mo, Zengnan, Qin, Xue, Lu, Zheng, Lin, Xinggu, Yao, Ziting, Jiang, Yonghua, Mao, Yan, Huang, Lirong, Liao, Ming, Wu, Chunlei
Format: Article
Language:English
Subjects:
Adult
Binding proteins
Body Mass Index
C-Reactive Protein - analysis
Cardiovascular disease
Complement C3 - analysis
Demographic aspects
Diabetes
Education
Graduate studies
Health aspects
Hospitals
Humans
Hyperglycemia
Immunoglobulin E - blood
Immunoglobulin G - blood
Immunoglobulins
Inflammation
Laboratories
Male
Males
Mens health
Metabolic diseases
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome - blood
Middle Aged
Obesity
Osteocalcin - blood
Physiological aspects
Population
Precision medicine
Science
Studies
Urology
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Summary:Osteocalcin (OCN) was potentially associated with inflammatory factors, so we explored the metabolic role in this association in general population. Our findings suggest that OCN was positively associated with IgG while inversely associated with C3, both of which were probably mediated by obesity. Moreover, serum OCN was inversely associated with hsCRP in men with impaired fasting glucose, hyperglycemia, or metabolic syndrome, while its association with IgE was significantly observed in men with a normal metabolic profile.
ISSN:0962-9351
1466-1861
DOI:10.1155/2015/683739