Pediatric living-donor liver transplantation using right posterior segment grafts

Background The right posterior segment (RPS) graft was introduced to overcome graft size discrepancy in living donor liver transplantation (LDLT). However, it was very rarely used in pediatric patients. Here we presented 4 pediatric LDLT cases receiving RPS graft between January 2015 and April 2020...

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Bibliographic Details
Published in:BMC gastroenterology 2021-06, Vol.21 (1), p.1-249, Article 249
Main Authors: Qu, Xiaoye, Wan, Ping, Feng, Mingxuan, Qiu, Bijun, Luo, Yi, Zhou, Tao, Zhu, Jianjun, Zhao, Dong, Gu, Guangxiang, Zhang, Jianjun, Xia, Qiang
Format: Article
Language:English
Subjects:
Angiography
Biliary atresia
Children
Cholestasis
Demographic aspects
Dissection
Donation of organs, tissues, etc
Donors
Gastroenterology
Hospitals
Live donor
Liver
Liver diseases
Liver transplantation
Liver transplants
Ornithine
Pediatric liver transplantation
Pediatric research
Pediatrics
Right posterior segment graft
Surgery
Sutures
Transplantation
Transplants & implants
Veins & arteries
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Summary:Background The right posterior segment (RPS) graft was introduced to overcome graft size discrepancy in living donor liver transplantation (LDLT). However, it was very rarely used in pediatric patients. Here we presented 4 pediatric LDLT cases receiving RPS graft between January 2015 and April 2020 in our center. A total of 1868 LDLT procedures were performed in this period. Methods Recipients included 1 boy and 3 girls with a median age of 45 months (range from 40 to 93 months). They were diagnosed with progressive familial intrahepatic cholestasis, propionic academia, ornithine transcarbamylase and biliary atresia, respectively. Four donors were all mothers with a median age of 32.5 years (31-38 years). Computer tomography angiography indicated posterior right branches branched off separately from main portal veins (type III variation). Three of these donor livers had 1 orifice of right hepatic veins (RHV). In the remaining 1 donor liver, the RHV showed 3 orifices and an outflow patch plastic was performed. Inferior right hepatic veins weren't found in four donor grafts. The median graft weight was 397.5 g (352-461 g) and the median graft-to-recipient weight ratio was 2.38% (1.44-2.80%). Results Postoperative complications occurred in neither donors nor recipients. Within the median follow-up duration of 29 months (14-64 months), four children are all alive with normal liver function. Conclusion In summary, for older children weighed more than 15 kg with donors' variation of type III portal veins, the use of RPS grafts could be a feasible and favorable option. Keywords: Pediatric liver transplantation, Live donor, Right posterior segment graft
ISSN:1471-230X
1471-230X
DOI:10.1186/s12876-021-01835-0