WVMDA: Predicting miRNA–Disease Association Based on Weighted Voting

An increasing number of experiments had verified that miRNA expression is related to human diseases. The miRNA expression profile may be an indicator of clinical diagnosis and provides a new direction for the prevention and treatment of complex diseases. In this work, we present a weighted voting-ba...

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Bibliographic Details
Published in:Frontiers in genetics 2021-09, Vol.12, p.742992-742992
Main Authors: Zhang, Zhen-Wei, Gao, Zhen, Zheng, Chun-Hou, Li, Lei, Qi, Su-Min, Wang, Yu-Tian
Format: Article
Language:English
Subjects:
credibility similarity
disease
Genetics
miRNA
miRNA-disease association
weighted voting
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Summary:An increasing number of experiments had verified that miRNA expression is related to human diseases. The miRNA expression profile may be an indicator of clinical diagnosis and provides a new direction for the prevention and treatment of complex diseases. In this work, we present a weighted voting-based model for predicting miRNA–disease association (WVMDA). To reasonably build a network of similarity, we established credibility similarity based on the reliability of known associations and used it to improve the original incomplete similarity. To eliminate noise interference as much as possible while maintaining more reliable similarity information, we developed a filter. More importantly, to ensure the fairness and efficiency of weighted voting, we focus on the design of weighting. Finally, cross-validation experiments and case studies are undertaken to verify the efficacy of the proposed model. The results showed that WVMDA could efficiently identify miRNAs associated with the disease.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2021.742992