Antimalarial activity of Cucumis metuliferus and Lippia kituiensis against Plasmodium berghei infection in mice

The search for new antimalarial drugs has become progressively urgent due to plasmodial resistance to most of the commercially available antimalarial drugs. As part of this effort, the study evaluated the antimalarial activity of and , which are traditionally used in Tanzania for the treatment of ma...

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Bibliographic Details
Published in:Research and reports in tropical medicine 2018-01, Vol.9, p.81-88
Main Authors: Mzena, Theopista, Swai, Hulda, Chacha, Musa
Format: Article
Language:English
Subjects:
Antimalarials
Biological products
Body weight
Crude extracts
Cucumis meturiferous
Dimethyl sulfoxide
Drug therapy
Esters
Health aspects
Lippia kituiensis
Malaria
Original Research
Pathogenic microorganisms
Plasmodium berghei
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Summary:The search for new antimalarial drugs has become progressively urgent due to plasmodial resistance to most of the commercially available antimalarial drugs. As part of this effort, the study evaluated the antimalarial activity of and , which are traditionally used in Tanzania for the treatment of malaria. In vivo antimalarial activity was assessed using the 4-day suppressive antimalarial assay. Mice were infected by injecting via tail vein 1×10 erythrocytes infected by ANKA. Extracts were administered orally; chloroquine (10 mg/kg/day) and dimethyl sulfoxide (5 mL/kg/day) were used as positive and negative controls, respectively. The level of parasitemia, survival time, packed cell volume (PCV) and variation in body weight of mice were used to determine the antimalarial activity of the extract. The ethyl acetate, methanolic and chloroform extracts of and significantly (
ISSN:1179-7282
1179-7282
DOI:10.2147/RRTM.S150091