Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s disease

• Published in: Scientific reports 2017-06, Vol.7 (1), p.4329-7, Article 4329
• Main Authors: Dileone, M., Carrasco-López, M. C., Segundo-Rodriguez, J. C., Mordillo-Mateos, L., López-Ariztegui, N., Alonso-Frech, F., Catalan-Alonso, M. J., Obeso, J. A., Oliviero, A., Foffani, G.
• Format: Article
• Language: English
• Subjects: 631/1647/1453/2105; 631/378/2632/1663; 631/443/376; 692/617/375/1718; Adult; Aged; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cerebral Cortex - physiopathology; Cortex (motor); Cortical Excitability; Dopamine; Dopamine - metabolism; Dopamine Agents - pharmacology; Dopamine Agents - therapeutic use; Dopamine receptors; Drugs; Evoked Potentials, Motor; Excitability; Female; Humanities and Social Sciences; Humans; Levodopa; Magnetic fields; Male; Middle Aged; Motor Cortex - metabolism; Motor Cortex - physiopathology; Motor evoked potentials; multidisciplinary; Parkinson Disease - drug therapy; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Parkinson's disease; Plasticity; Science; Science (multidisciplinary); Transcranial Magnetic Stimulation
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-04254-y

Transcranial static magnetic field stimulation (tSMS) is a recent low-cost non-invasive brain stimulation technique that decreases cortical excitability in healthy subjects. The objective of the present study was to test the ability of tSMS to modulate cortical excitability in patients with Parkinson’s disease. We performed a randomized double-blind sham-controlled cross-over study to assess cortical excitability before and immediately after tSMS (or sham) applied for 10 min to the more affected motor cortex of patients with Parkinson’s disease. Cortical excitability was quantified by the amplitude of motor evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS). tSMS significantly decreased MEP amplitudes in patients OFF medication (after overnight withdrawal of dopaminergic drugs), but not ON medication (after an acute dose of levodopa). The between-patients variability of tSMS-induced changes was significantly greater ON medication. The variability ON medication could be partly explained by disease progression, i.e. the more advanced the patient, the more likely it was to observe a switch from inhibitory tSMS plasticity OFF medication to paradoxical facilitatory plasticity ON medication. These results suggest that tSMS induces dopamine-dependent changes of cortical excitability in patients with Parkinson’s disease.