Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis

Osteoarthritis, as a degenerative disease, is a common problem and results in high socioeconomic costs and rates of disability. The most commonly affected joint is the knee and characterized by progressive destruction of articular cartilage, loss of extracellular matrix, and progressive inflammation...

Full description

Saved in:
Bibliographic Details
Published in:Stem cell research & therapy 2022-01, Vol.13 (1), p.14-14, Article 14
Main Authors: Xiang, Xiao-Na, Zhu, Si-Yi, He, Hong-Chen, Yu, Xi, Xu, Yang, He, Cheng-Qi
Format: Article
Language:English
Subjects:
Amniotic fluid
Antiarthritic agents
Antigens
Apoptosis
Arthritis
Body fat
Bone marrow
Cartilage
Cartilage diseases
Cartilage, Articular
Cell adhesion & migration
Cell culture
Exosome
Exosomes
Extracellular Matrix
Fibroblasts
Glycoproteins
Growth factors
Humans
Inflammation
Knee
Melanoma
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Mesenchymal stromal cell
Mesenchyme
Osteoarthritis
Osteoarthritis, Knee - therapy
Proteins
Regeneration
Review
Stem cells
Umbilical cord
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Osteoarthritis, as a degenerative disease, is a common problem and results in high socioeconomic costs and rates of disability. The most commonly affected joint is the knee and characterized by progressive destruction of articular cartilage, loss of extracellular matrix, and progressive inflammation. Mesenchymal stromal cell (MSC)-based therapy has been explored as a new regenerative treatment for knee osteoarthritis in recent years. However, the detailed functions of MSC-based therapy and related mechanism, especially of cartilage regeneration, have not been explained. Hence, this review summarized how to choose, authenticate, and culture different origins of MSCs and derived exosomes. Moreover, clinical application and the latest mechanistical findings of MSC-based therapy in cartilage regeneration were also demonstrated.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-021-02689-9