Pulmonary Inflammatory Myofibroblastic Tumor: A Case Report

An inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that occurs predominantly in children and young adults. Etiology remains unclear. But based on the frequent detection of chromosomic alterations, especially near the anaplastic lymphoma kinase (ALK) gene, IMT is now considered t...

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Published in:European journal of pediatric surgery reports 2024-01, Vol.12 (1), p.e73-e76
Main Authors: Bruyninckx, Lotte, De Leyn, Paul, Van Raemdonck, Dirk, Jansen, Yanina, Coppens, Katrien, Vermeulen, Francois, Weynand, Birgit, Gieraerts, Christopher, Decaluwé, Herbert
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Language:English
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anaplastic lymphoma kinase
Case Report
histopathology
inflammatory myofibroblastic tumor
pediatric surgery
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container_title European journal of pediatric surgery reports
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creator Bruyninckx, Lotte
De Leyn, Paul
Van Raemdonck, Dirk
Jansen, Yanina
Coppens, Katrien
Vermeulen, Francois
Weynand, Birgit
Gieraerts, Christopher
Decaluwé, Herbert
description An inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that occurs predominantly in children and young adults. Etiology remains unclear. But based on the frequent detection of chromosomic alterations, especially near the anaplastic lymphoma kinase (ALK) gene, IMT is now considered to be a true neoplasm. In addition, the possible aggressive behavior, and the ability to metastasize suggest at least an intermediate malignant potential. Surgery remains the treatment of choice, but the use of chemotherapy, nonsteroidal anti-inflammatory drugs, immunotherapy, and targeted therapy are reported. We describe a case of a pulmonary IMT in a 6-year-old boy with an incidental finding of a lesion in the right upper lobe. A video-assisted thoracoscopic right upper lobectomy with lymph node resection was performed. Microscopic examination confirmed the diagnosis of IMT with the nodule showing spindle cells in a background of plasma cells. ALK immunohistochemical expression was negative.
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subjects anaplastic lymphoma kinase
Case Report
histopathology
inflammatory myofibroblastic tumor
pediatric surgery
title Pulmonary Inflammatory Myofibroblastic Tumor: A Case Report
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