Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution

Cerebrovascular reactivity (CVR) is typically assessed with a carbon dioxide (CO ) stimulus combined with BOLD fMRI. Recently, resting-state (RS) BOLD fMRI has been shown capable of generating CVR maps, providing a potential for broader CVR applications in neuroimaging studies. However, prior RS-CVR...

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Bibliographic Details
Published in:Frontiers in neuroimaging 2023-06, Vol.2, p.1205459-1205459
Main Authors: Liu, Peiying, Hu, Beini, Kartchner, Lincoln, Joshi, Parimal, Xu, Cuimei, Jiang, Dengrong
Format: Article
Language:English
Subjects:
cerebrovascular reactivity (CVR)
duration-dependence
Neuroimaging
reproducibility
resolution-dependence
resting-state fMRI
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Summary:Cerebrovascular reactivity (CVR) is typically assessed with a carbon dioxide (CO ) stimulus combined with BOLD fMRI. Recently, resting-state (RS) BOLD fMRI has been shown capable of generating CVR maps, providing a potential for broader CVR applications in neuroimaging studies. However, prior RS-CVR studies have primarily been performed at a spatial resolution of 3-4 mm voxel sizes. It remains unknown whether RS-CVR can also be obtained at high-resolution without major degradation in image quality. In this study, we investigated RS-CVR mapping based on resting-state BOLD MRI across a range of spatial resolutions in a group of healthy subjects, in an effort to examine the feasibility of RS-CVR measurement at high resolution. Comparing the results of RS-CVR with the maps obtained by the conventional CO2-inhalation method, our results suggested that good CVR map quality can be obtained at a voxel size as small as 2 mm isotropic. Our results also showed that, RS-CVR maps revealed resolution-dependent sensitivity. However, even at a high resolution of 2 mm isotropic voxel size, the voxel-wise sensitivity is still greater than that of typical task-evoked fMRI. Scan duration affected the sensitivity of RS-CVR mapping, but had no significant effect on its accuracy. These findings suggest that RS-CVR mapping can be applied at a similar resolution as state-of-the-art fMRI studies, which will broaden the use of CVR mapping in basic science and clinical applications including retrospective analysis of previously collected fMRI data.
ISSN:2813-1193
2813-1193
DOI:10.3389/fnimg.2023.1205459