Progressive Thickening of Retinal Nerve Fiber and Ganglion Cell Complex Layers Following SDM Laser Vision Protection Therapy in Open-Angle Glaucoma

Introduction This work aims to determine the effect on nerve fiber layer (NFL) and ganglion cell complex (GCC) thickness trends in eyes with open-angle glaucoma (OAG) treated with Vision Protection Therapy™ (VPT). Methods A retrospective analysis of spectral-domain optical coherence tomography (OCT)...

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Bibliographic Details
Published in:Ophthalmology and therapy 2024-11, Vol.13 (11), p.2903-2918
Main Authors: Luttrull, Jeffrey K., Tzekov, Radouil, Bhavan, Sathy V.
Format: Article
Language:English
Subjects:
Ganglion cell complex
Internal Medicine
Laser
Medicine
Medicine & Public Health
Nerve fiber layer
Ophthalmology
Original Research
SDM
Trends
Vision protection therapy
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Summary:Introduction This work aims to determine the effect on nerve fiber layer (NFL) and ganglion cell complex (GCC) thickness trends in eyes with open-angle glaucoma (OAG) treated with Vision Protection Therapy™ (VPT). Methods A retrospective analysis of spectral-domain optical coherence tomography (OCT) measured NFL and GCC thickness trends was performed, excluding eyes with poor-quality scans and principal diagnoses other than OAG. This study compares eyes with OAG managed conventionally with IOP control alone (controls) to eyes managed with the addition of VPT (VPT eyes). The direction (+ or −) and magnitude (microns/year) of the OCT trends were the study endpoints. Results Seventy-eight control eyes of 40 patients and 61 VPT-treated eyes of 39 patients were included in the study. Positive NFL trends were noted in 5% of control eyes vs. 71% of VPT eyes ( p  
ISSN:2193-8245
2193-6528
DOI:10.1007/s40123-024-01029-3