Progressive multifocal leukoencephalopathy selectively affecting Broca's and Wernicke's areas in an immunocompetent patient: A case report

Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal, demyelinating disease of the central nervous system. The disease almost exclusively presents in immunosuppressed patients, such as those with acquired immunodeficiency syndrome, a hematopoietic malignancy, or a transplanted org...

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Bibliographic Details
Published in:Radiology case reports 2023-03, Vol.18 (3), p.1334-1336
Main Authors: Kim, Renaid B., Irani, David N., Kim, John
Format: Article
Language:English
Subjects:
Case Report
Encephalopathy
JC polyomavirus
Progressive multifocal leukoencephalopathy
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Summary:Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal, demyelinating disease of the central nervous system. The disease almost exclusively presents in immunosuppressed patients, such as those with acquired immunodeficiency syndrome, a hematopoietic malignancy, or a transplanted organ; it is extremely rare in patients without immunosuppression. We present a case of a 74-year-old female with radiographic and histopathological findings consistent with PML that possibly arose in the setting of Sjögren's-related vasculitis but no immunosuppression.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2023.01.011