Advances in ATR-FTIR Spectroscopic Imaging for the Analysis of Tablet Dissolution and Drug Release

One of the major challenges in the development of effective pharmaceutical formulations for oral administration is the poor solubility of active pharmaceutical ingredients. For this reason, the dissolution process and drug release from solid oral dosage forms, such as tablets, is usually thoroughly...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-06, Vol.28 (12), p.4705
Main Authors: van Haaren, Céline, De Bock, Marieke, Kazarian, Sergei G
Format: Article
Language:English
Subjects:
chemical imaging
Diagnostic Imaging
Dissolution
Dosage
Drug dosages
Drug Liberation
drug release
Formulations
FTIR spectroscopic imaging
Imaging techniques
Infrared spectroscopy
Magnetic resonance imaging
Mandatory drug testing
Molecular structure
Optimization
Oral administration
Pharmaceutical industry
Pharmaceuticals
Review
solid oral dosage forms
Solubility
Spectroscopy, Fourier Transform Infrared - methods
Spectrum analysis
Tablets - chemistry
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Summary:One of the major challenges in the development of effective pharmaceutical formulations for oral administration is the poor solubility of active pharmaceutical ingredients. For this reason, the dissolution process and drug release from solid oral dosage forms, such as tablets, is usually thoroughly studied in order to understand the dissolution behaviour under various conditions and optimize the formulation accordingly. Standard dissolution tests used in the pharmaceutical industry provide information on the amount of drug released over time; however, these do not allow for a detailed analysis of the underlying chemical and physical mechanisms of tablet dissolution. FTIR spectroscopic imaging, by contrast, does offer the ability to study these processes with high spatial and chemical specificity. As such, the method allows us to see the chemical and physical processes which occur inside the tablet as it dissolves. In this review, the power of ATR-FTIR spectroscopic imaging is demonstrated by presenting a number of successful applications of this chemical imaging technique to dissolution and drug release studies for a range of different pharmaceutical formulations and study conditions. Understanding these processes is essential for the development of effective oral dosage forms and optimization of pharmaceutical formulations.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28124705