Whole blood viscosity in microvascular angina and coronary artery disease: Significance and utility

Whole blood viscosity (WBV) is the intrinsic resistance of blood flow in vessels, and when elevated induces endothelial shear stress and endothelial inflammation and can accelerate the atherosclerotic process. This study aims to compare WBV levels in patients with microvascular angina (MVA), patient...

Full description

Saved in:
Bibliographic Details
Published in:Revista portuguesa de cardiologia 2020-01, Vol.39 (1), p.17-23
Main Authors: Cekirdekci, Elif Ijlal, Bugan, Baris
Format: Article
Language:English
Subjects:
Aged
Angina microvascular
Blood viscosity
Blood Viscosity - physiology
C-reactive protein
C-Reactive Protein - analysis
Case-Control Studies
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - pathology
Coronary Artery Disease - physiopathology
Doença arterial coronária
Female
Hematocrit - methods
Humans
Inflammation - metabolism
Male
Microvascular angina
Microvascular Angina - blood
Microvascular Angina - pathology
Microvascular Angina - physiopathology
Middle Aged
Non-Randomized Controlled Trials as Topic
Proteína C-reativa
Retrospective Studies
Serum Albumin, Human - analysis
Serum Globulins - analysis
Viscosidade sanguínea
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Whole blood viscosity (WBV) is the intrinsic resistance of blood flow in vessels, and when elevated induces endothelial shear stress and endothelial inflammation and can accelerate the atherosclerotic process. This study aims to compare WBV levels in patients with microvascular angina (MVA), patients with coronary artery disease (CAD), and normal controls, and to identify the relationship between WBV and high-sensitivity C-reactive protein as a marker of inflammation in MVA and CAD. A total of 573 patients were studied. The MVA group consisted of 189 subjects, the CAD group consisted of 203 subjects, and the control group consisted of 181 age- and gender-matched individuals. WBV was calculated from hematocrit and plasma protein concentration at a low shear rate (0.5 s–1) and high shear rate (208 s–1) by a validated equation. Patients with CAD and MVA had significantly higher WBV at both low and high shear rates compared to the control group. Correlation analysis revealed a significant relationship between high-sensitivity C-reactive protein and WBV at low (r=0.556; p
ISSN:0870-2551
2174-2030
2174-2049
DOI:10.1016/j.repc.2019.04.008