Prognostic value of immuno-inflammatory biomarkers in esophageal squamous cell carcinoma patients receiving immunotherapy combined with chemoradiotherapy and its association with immuno-genomic landscape

The clinical significance of immuno-inflammatory indicators and the underlying biological basis in patients with esophageal squamous cell carcinoma (ESCC) who receive chemoradiotherapy (CRT) combined with immunotherapy remains unclear. This study aims to evaluate the prognostic value of immuno-infla...

Full description

Saved in:
Bibliographic Details
Published in:BMC cancer 2024-12, Vol.24 (1), p.1518-12
Main Authors: Cheng, Xingyuan, Meng, Fanjun, Wang, Ruixi, Liu, Shiliang, Li, Qiaoqiao, Chen, Baoqing, Xi, Mian
Format: Article
Language:English
Subjects:
Aged
Analysis
Biological markers
Biomarkers, Tumor
Cancer
Care and treatment
Chemoradiotherapy
Chemoradiotherapy - methods
Chemotherapy
Development and progression
Drug therapy
Esophageal cancer
Esophageal Neoplasms - immunology
Esophageal Neoplasms - mortality
Esophageal Neoplasms - therapy
Esophageal squamous cell carcinoma
Esophageal Squamous Cell Carcinoma - immunology
Esophageal Squamous Cell Carcinoma - mortality
Esophageal Squamous Cell Carcinoma - pathology
Esophageal Squamous Cell Carcinoma - therapy
Female
Genetic aspects
Health aspects
Humans
Immune system
Immuno-inflammatory biomarkers
Immunogenomic landscape
Immunotherapy
Immunotherapy - methods
Inflammation
Male
Medical research
Medicine, Experimental
Middle Aged
Neutrophils
Nomograms
Physiological aspects
Prognosis
Radiotherapy
Retrospective Studies
RNA sequencing
Squamous cell carcinoma
T cells
Tumor Microenvironment - immunology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The clinical significance of immuno-inflammatory indicators and the underlying biological basis in patients with esophageal squamous cell carcinoma (ESCC) who receive chemoradiotherapy (CRT) combined with immunotherapy remains unclear. This study aims to evaluate the prognostic value of immuno-inflammatory biomarkers, develop a prognostic model, and explore the underlying mechanisms. This study included 212 ESCC patients who received CRT and anti-PD-1 immunotherapy. Association between progression-free survival (PFS) and immuno-inflammatory biomarkers, including absolute lymphocyte count (ALC), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio was analyzed. A nomogram was built based on the independent prognostic factors identified using multivariable Cox regression model. Pre-treatment tumor samples from 47 patients were collected for RNA sequencing to investigate the immune-related tumor microenvironment. Patients experienced significant changes in immuno-inflammatory biomarkers during CRT, which gradually recovered after radiotherapy. Body mass index 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-024-13298-z