High plasma levels of pro-inflammatory factors interleukin-17 and interleukin-23 are associated with poor outcome of cardiac-arrest patients: a single center experience

Systemic inflammation is an important feature of post-cardiac arrest syndrome (PCAS). This study was designed to determine whether the plasma concentrations of some circulating pro-inflammatory cytokines (interleukin-17 [IL-8], IL-22, IL-23 and IL-33) are of value in predicting the outcome of patien...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2020-04, Vol.20 (1), p.170-170, Article 170
Main Authors: Zhuang, Yu-Gang, Chen, Yuan-Zhuo, Zhou, Shu-Qin, Peng, Hu, Chen, Yan-Qing, Li, Dong-Jie
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Aspartate aminotransferase
Biomarkers
Cardiac arrest
Cardiopulmonary resuscitation
CPR
Creatinine
Cytokines
Health aspects
Heart
IL-17
IL-23
Inflammation
Intensive care
Interleukin 17
Interleukin 22
Interleukin 23
Interleukin 8
Interleukins
Ischemia
Mortality
Patients
Physiological aspects
Plasma levels
Post-cardiac arrest syndrome
Proteins
ROSC
Studies
Tumor necrosis factor-TNF
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Summary:Systemic inflammation is an important feature of post-cardiac arrest syndrome (PCAS). This study was designed to determine whether the plasma concentrations of some circulating pro-inflammatory cytokines (interleukin-17 [IL-8], IL-22, IL-23 and IL-33) are of value in predicting the outcome of patients after return of spontaneous circulation (ROSC) during the post-cardiac arrest period. This was a prospective observational clinical study. In total, 21 patients (survivors, n = 10; non-survivors, n = 11) who experienced cardiac arrest and successful ROSC with expected survival of at least 7 days were consecutively enrolled from January 2016 to December 2017. Of the 21 enrolled patients, ten survived were designated "survivors". The other eleven patients died between 2 days and 1 months post ROSC. Venous blood was drawn at three time-points: baseline (
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-020-01451-y