Correlation between atherogenic risk and adiponectin in gestational diabetes mellitus

Introduction and objective. Gestational diabetes mellitus (GDM) is a pregnancy complication which increases the risk for maternal and foetal complications during pregnancy, and also significantly increases the cardiovascular risk for women’s health in the postpartum. Current literature provides cont...

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Bibliographic Details
Published in:Annals of Agricultural and Environmental Medicine 2014-03, Vol.21 (872203), p.143-147
Main Authors: Beata Matyjaszek-Matuszek, Monika Lenart-Lipińska, Jolanta Kowalczyk-Bołtuć, Wojciech Szlichtyng, Tomasz Paszkowski
Format: Article
Language:English
Subjects:
CRP
Fibrinogen
atherogenic risk
Insulin Resistance
gestational diabetes
Adiponectin
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Summary:Introduction and objective. Gestational diabetes mellitus (GDM) is a pregnancy complication which increases the risk for maternal and foetal complications during pregnancy, and also significantly increases the cardiovascular risk for women’s health in the postpartum. Current literature provides contradictory information on the role of adiponectin (AdipoQ) in the course of GDM. The aim of the study was to measure AdipoQ concentration in blood of women with GDM and to find correlations between this adipokine and clinical and biochemical parameters of the atherogenic risk. Material and methods. The GDM group included 50 women diagnosed with GDM between 24 – 28 weeks of gestation who underwent routine prenatal tests for GDM in compliance with the guidelines of the Polish Diabetes Association. All patients underwent clinical and laboratory evaluation at GDM diagnosis. Laboratory tests included serum AdipoQ concentration, fasting glucose and insulin, OGTT, lipid parameters, C-reactive protein and fibrinogen in serum. Results. The GDM group showed significantly elevated fasting glucose, insulin, HOMA-IR values, total cholesterol, LDLcholesterol and triglicerydes as compared with the control group (p
ISSN:1232-1966
1898-2263