Green-Synthesized Silver Nanoparticles: Antifungal and Cytotoxic Potential for Further Dental Applications

Fungal infections caused by ( ) are one of the most prevalent types of oral disorders in the elderly. It has been reported that drug resistance to fungal pathogens poses a severe risk to global healthcare systems and public health. Therefore, the goal of this work is to investigate the cytotoxic and...

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Bibliographic Details
Published in:Journal of functional biomaterials 2023-07, Vol.14 (7), p.379
Main Authors: Klein, Widadh, Ismail, Enas, Maboza, Ernest, Hussein, Ahmed A, Adam, Razia Z
Format: Article
Language:English
Subjects:
Antifungal activity
Antifungal agents
Berzelia lanuginose
Buccal mucosa
Candida albicans
Computer software industry
Cytotoxicity
Dental materials
Dental research
Drug resistance
Fibroblasts
Fungi
Fungicides
Global health
green synthesis
Health risks
Helichrysum cymosum
Minimum inhibitory concentration
Nanoparticles
Plant extracts
Public health
Searsia crenata
Silver
silver nanoparticles
Software
Surface plasmon resonance
Synthesis
Toxicity
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Summary:Fungal infections caused by ( ) are one of the most prevalent types of oral disorders in the elderly. It has been reported that drug resistance to fungal pathogens poses a severe risk to global healthcare systems and public health. Therefore, the goal of this work is to investigate the cytotoxic and antifungal properties of silver nanoparticles (AgNPs) produced using three different natural extracts: , , and . According to the UV-Vis results, the synthesized AgNPs via , , and show surface plasmonic resonance (SPR) peaks at 430, 440, and 428 nm, respectively. HR-TEM revealed different shapes for the nanoparticles within the size ranges of 16-20, 31-60, and 57-72 nm for , , and , respectively. Using a human oral fibroblast cell line, the cytotoxicity of both AgNPs and plant extracts was tested at concentrations of 0.007, 0.012, 0.025, and 0.062 mg/mL (buccal mucosa fibroblasts). The antifungal activity showed growth inhibition zones of approximately 18 mm, 18.67 mm, and 18.33 mm for the AgNPs conjugated with , , and respectively. For the studied samples, the minimum inhibitory concentration (MIC ) was less than 0.015 mg/mL. The AgNPs exhibited antifungal activity that was concentration- and size-dependent. The results of this study offer new insights into the cytotoxicity and antifungal activity of the green-synthesized AgNPs.
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb14070379