A Polymorphism of ORAI1 rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis

Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases...

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Published in:Mediators of Inflammation 2014-01, Vol.2014 (8), p.301-305
Main Authors: Chang, Wei Chiao, Wu, Man-Tzu Marcie, Chen, Ben-Kuen, Hwang, Daw-Yang, Wu, Mei-Shin, Lee, Chih-Hung, Hsu, Yu-Wen, Chang, Che-Mai, Yen, Jeng-Hsien, Liao, Hsien-Tzung
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Arthritis, Rheumatoid - genetics
Calcium Channels - genetics
Case-Control Studies
Child
Female
Genetic Predisposition to Disease - genetics
Humans
Male
Middle Aged
ORAI1 Protein
Polymorphism, Single Nucleotide - genetics
Young Adult
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Summary:Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.
ISSN:0962-9351
1466-1861
DOI:10.1155/2014/834831