Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements

• Published in: Scientific reports 2018-10, Vol.8 (1), p.15691-10, Article 15691
• Main Authors: Sidiropoulou, Elpida J., Paltoglou, George, Valsamakis, George, Margeli, Alexandra, Mantzou, Aimilia, Papassotiriou, Ioannis, Hassiakos, Dimitrios, Iacovidou, Nicoletta, Mastorakos, George
• Format: Article
• Language: English
• Subjects: 692/163/2743/2037; 692/308/3187; 692/308/53/2423; Adiponectin; Adiponectin - blood; Adiponectin Concentrations; Alanine Transaminase - blood; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics; Analysis of Variance; Anthropometry; Aspartate Aminotransferases - blood; Biochemistry; Birth Weight; Blood Glucose; Carbohydrate Metabolism - physiology; Chi-Square Distribution; Child; Child, Preschool; Children; Cholesterol; Cohort Studies; Creatinine; Creatinine - blood; Cross-Sectional Studies; Epidermal growth factor receptors; Female; Females; Fetal Growth Retardation - genetics; Fetal Growth Retardation - metabolism; Gestational Age; Glucagon; Glucose Metabolism Parameters; High density lipoprotein; Humanities and Social Sciences; Humans; Infant; Insulin; Insulin - blood; Insulin Resistance; Intrauterine Growth Restriction (IUGR); Leptin; Leptin - blood; Liver; Low density lipoprotein; Male; Males; Metabolic syndrome; multidisciplinary; Peptides; Polymorphism; Polymorphism, Genetic; Pregnancy; Quantitative Insulin Sensitivity Check Index (QUICKI); Renal Derangement; Science; Science (multidisciplinary); Triglycerides; Triglycerides - blood; Urea; Uric acid; Uric Acid - blood
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-34075-6

Children born with IUGR develop features of the metabolic syndrome and exhibit deranged markers of hepatorenal physiology. Metabolic and hepatorenal biochemistry and the rs9939609 FTO polymorphism were investigated in prepubertal children born with IUGR. Ninety-eight prepubertal children (46 IUGR and 52 AGA), subdivided in 5 years old groups were included. Anthropometry; creatinine, eGFR, urea, AST, ALT, triglycerides, uric acid, total cholesterol, HDL-c, LDL-c, glucose, C-peptide, insulin and glucagon z-scores; HOMA-IR; leptin and adiponectin concentrations; rs9939609 FTO polymorphism frequency were measured. In males, weight and ALT were higher and adiponectin was lower, in IUGR  5 years; C-peptide was higher in all IUGR, than the respective AGA. In females, creatinine and triglycerides were higher in IUGR