A Portable Low-Power Acquisition System with a Urease Bioelectrochemical Sensor for Potentiometric Detection of Urea Concentrations

This paper presents a portable low-power battery-driven bioelectrochemical signal acquisition system for urea detection. The proposed design has several advantages, including high performance, low cost, low-power consumption, and high portability. A LT1789-1 low-supply-voltage instrumentation amplif...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2016-04, Vol.16 (4), p.474-474
Main Authors: Ma, Wei-Jhe, Luo, Ching-Hsing, Lin, Jiun-Ling, Chou, Sin-Houng, Chen, Ping-Hung, Syu, Mei-Jywan, Kuo, Shin-Hung, Lai, Shin-Chi
Format: Article
Language:English
Subjects:
Acquisitions
Amplification
Aniline Compounds - chemistry
battery-driven
bioelectrochemical signal acquisition
Biosensing Techniques - instrumentation
Biosensors
Design
Devices
Electrodes
Engineering
Enzymes, Immobilized - chemistry
Hemodialysis
Humans
immobilized urease
Marketing
MEMS
Personal health
Polymers - chemistry
Portability
portable
potentiometric
Sensors
urea
Urea - chemistry
Urea - isolation & purification
Ureas
Urease - chemistry
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Summary:This paper presents a portable low-power battery-driven bioelectrochemical signal acquisition system for urea detection. The proposed design has several advantages, including high performance, low cost, low-power consumption, and high portability. A LT1789-1 low-supply-voltage instrumentation amplifier (IA) was used to measure and amplify the open-circuit potential (OCP) between the working and reference electrodes. An MSP430 micro-controller was programmed to process and transduce the signals to the custom-developed software by ZigBee RF module in wireless mode and UART in able mode. The immobilized urease sensor was prepared by embedding urease into the polymer (aniline-co-o-phenylenediamine) polymeric matrix and then coating/depositing it onto a MEMS-fabricated Au working electrode. The linear correlation established between the urea concentration and the potentiometric change is in the urea concentrations range of 3.16 × 10(-4) to 3.16 × 10(-2) M with a sensitivity of 31.12 mV/log [M] and a precision of 0.995 (R² = 0.995). This portable device not only detects urea concentrations, but can also operate continuously with a 3.7 V rechargeab-le lithium-ion battery (500 mA·h) for at least four days. Accordingly, its use is feasible and even promising for home-care applications.
ISSN:1424-8220
1424-8220
DOI:10.3390/s16040474