Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances

• Published in: World journal of surgical oncology 2011-12, Vol.9 (1), p.158-158, Article 158
• Main Authors: Ren, Juchao, Liu, Hainan, Yan, Lei, Tian, Sujian, Li, Dawei, Xu, Zhonghua
• Format: Article
• Language: English
• Subjects: Angiogenesis; Cancer; Cancer therapies; Carcinoma, Renal cell; Carcinoma, Renal Cell - blood supply; Carcinoma, Renal Cell - enzymology; Carcinoma, Renal Cell - mortality; Care and treatment; clear cell renal cell carcinoma; Diagnosis; Female; Glucuronidase - genetics; Glucuronidase - metabolism; heparanase; Hospitalization; Humans; Immunoenzyme Techniques; Immunohistochemistry; Kidney Neoplasms - blood supply; Kidney Neoplasms - enzymology; Kidney Neoplasms - mortality; Lymphatic Metastasis; Male; microvessel density; Microvessels - pathology; Middle Aged; Neovascularization, Pathologic; Polymerase chain reaction; Prognosis; Proteins; Public health; Real-Time Polymerase Chain Reaction; RNA, Messenger - genetics; Signal transduction; Survival Rate; Tumors
• ISSN: 1477-7819; 1477-7819
• DOI: 10.1186/1477-7819-9-158

Tumor angiogenesis is important in the progression of malignancies, and heparanase plays an important role in sustaining the pathology of clear cell renal cell cancer (ccRCC). The study was carried out to investigate the correlations between microvessel density (MVD) and heparanase expression containing prognostic significances in the patients with ccRCC. Specimens from 128 patients with ccRCC were investigated by immunohistochemistry for MVD. RT-PCR and immunohistochemistry were used to detect heparanase expression. Correlations between MVD, heparanase expression, and various clinico-pathological factors were studied. The prognostic significances of MVD and heparanase expression were also analysed. We discovered a statistically significant prevalence of higher MVD in ccRCC compared with adjacent normal renal tissues. MVD was positively correlated with TNM stage and distant metastasis in ccRCC patients, and was also correlated with the expression level of heparanase.Heparanase is over-expressed and correlated with TNM stage, histologic grade, distant metastasis and lymphatic metastasis in ccRCC. High MVD and heparanase over-expression inversely correlate with the survival of ccRCC patients. Heparanase contributes to angiogenesis of ccRCC and over-expression of heparanase is an independent predictors of prognosis for ccRCC. MVD is correlated with tumor development and metastasis in ccRCC.