Phytocompounds from Amazonian Plant Species against Acute Kidney Injury: Potential Nephroprotective Effects

There are several Amazonian plant species with potential pharmacological validation for the treatment of acute kidney injury, a condition in which the kidneys are unable to adequately filter the blood, resulting in the accumulation of toxins and waste in the body. Scientific production on plant comp...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-09, Vol.28 (17), p.6411
Main Authors: Paes, Alberto Souza, Koga, Rosemary de Carvalho Rocha, Sales, Priscila Faimann, Santos Almeida, Hellen Karine, Teixeira, Thiago Afonso Carvalho Celestino, Carvalho, José Carlos Tavares
Format: Article
Language:English
Subjects:
Alkaloids
Amazonian traditional medicine
Analysis
antioxidant
Antioxidants
Biodiversity
Biological activity
Chemical compounds
Drugs
Electrolytes
Flavonoids
Flowers & plants
Health aspects
Heart failure
Hemodynamics
Hypoxia
Ischemia
Isoflavones
Kidneys
Medical research
Medicine, Experimental
Metabolites
Mortality
nephroprotection
Nitrogen
oxidative stress
Phytochemicals
phytotherapy
Review
Socioeconomic factors
Toxicity
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Summary:There are several Amazonian plant species with potential pharmacological validation for the treatment of acute kidney injury, a condition in which the kidneys are unable to adequately filter the blood, resulting in the accumulation of toxins and waste in the body. Scientific production on plant compounds capable of preventing or attenuating acute kidney injury—caused by several factors, including ischemia, toxins, and inflammation—has shown promising results in animal models of acute kidney injury and some preliminary studies in humans. Despite the popular use of Amazonian plant species for kidney disorders, further pharmacological studies are needed to identify active compounds and subsequently conduct more complex preclinical trials. This article is a brief review of phytocompounds with potential nephroprotective effects against acute kidney injury (AKI). The classes of Amazonian plant compounds with significant biological activity most evident in the consulted literature were alkaloids, flavonoids, tannins, steroids, and terpenoids. An expressive phytochemical and pharmacological relevance of the studied species was identified, although with insufficiently explored potential, mainly in the face of AKI, a clinical condition with high morbidity and mortality.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28176411