Pulmonary Metastasising Aneurysmal Fibrous Histiocytoma: A Case Report, Literature Review and Proposal of Standardised Diagnostic Criteria

An aneurysmal fibrous histiocytoma is a rare cutaneous soft-tissue tumour which accounts for approximately 0.06% of all dermatopathologies. Metastasis is exceedingly uncommon, to the point that there have only been eight reported cases in the scientific literature. We present the case of a 25-year-o...

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Bibliographic Details
Published in:Diseases 2023-08, Vol.11 (3), p.108
Main Authors: Mankertz, Fiona, Keßler, Rebecca, Rau, Andrea, Seebauer, Christian, Ribback, Silvia, Busemann, Alexandra
Format: Article
Language:English
Subjects:
AFH
Aneurysm
aneurysmal fibrous histiocytoma
angiomatoid fibrous histiocytoma
Biopsy
Case Report
Case reports
Complications and side effects
Dermatofibroma
Diagnosis
Differential diagnosis
Histiocytoma
Literature reviews
Lung cancer
Medical imaging
Metastases
Metastasis
Morphology
Pediatrics
Tumors
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Summary:An aneurysmal fibrous histiocytoma is a rare cutaneous soft-tissue tumour which accounts for approximately 0.06% of all dermatopathologies. Metastasis is exceedingly uncommon, to the point that there have only been eight reported cases in the scientific literature. We present the case of a 25-year-old male with a primary aneurysmal fibrous histiocytoma located in the nuchal region which exhibited rapid growth and abrupt ulceration over a short time span and showed signs of locoregional aggressive infiltration. A subsequent histopathological analysis confirmed the presence of diffuse solid and cystic pulmonary metastases. Further genetic sequencing verified LAMTOR1-PRKCD fusion. This case report seeks to review the existing literature on aneurysmal fibrous histiocytoma, discuss the challenges of differential diagnosis and propose standardised diagnostic criteria.
ISSN:2079-9721
2079-9721
DOI:10.3390/diseases11030108