Host modulation by therapeutic agents

Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at br...

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Published in:Journal of pharmacy & bioallied science 2012-08, Vol.4 (Suppl 2), p.S256-S259
Main Authors: Elavarasu, Sugumari, Sekar, Santhosh, Murugan, Thamaraiselvan
Format: Article
Language:English
Subjects:
Cytokines
Dental Science - Review
Kinases
Matrix metalo protienases (MMP)
Nonsteroidal anti-inflammatory drugs
Periodontitis
Proteins
Rodents
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creator Elavarasu, Sugumari
Sekar, Santhosh
Murugan, Thamaraiselvan
description Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level. Doxycycline, nonsteroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, nitrous oxide (NO) synthase inhibitors, recombinant human interleukin-11 (rhIL-11), omega-3 fatty acid, mouse anti-human interleukin-6 receptor antibody (MRA), mitogen-activated protein kinase (MAPK) inhibitors, nuclear factor-kappa B (NF-kb) inhibitors, osteoprotegerin, and tumor necrosis factor antagonist (TNF-α) are some of the therapeutic agents that have host modulation properties.
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source Publicly Available Content Database; IngentaConnect Journals; PubMed Central
subjects Cytokines
Dental Science - Review
Kinases
Matrix metalo protienases (MMP)
Nonsteroidal anti-inflammatory drugs
Periodontitis
Proteins
Rodents
title Host modulation by therapeutic agents
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