Apolipoprotein A-V Is a Novel Diagnostic and Prognostic Predictor in Pediatric Patients with Sepsis: A Prospective Pilot Study in PICU

Background. Sepsis induces the release of lipid mediators, which control both lipid metabolism and inflammation. However, the role of serum apolipoprotein A-V (ApoA5) in sepsis is poorly understood in pediatric patients. Methods. ApoA5 was screened from serum proteomics profile in lipopolysaccharide...

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Bibliographic Details
Published in:Mediators of inflammation 2020, Vol.2020 (2020), p.1-9
Main Authors: Zhang, Yucai, Shao, Lujing, Dou, Jiaying, Xiong, Xi, Miao, Huijie, Cui, Yun, Wang, Chunxia, Tang, Xiaomeng
Format: Article
Language:English
Subjects:
Age
Analysis
Apolipoprotein A
Apolipoprotein A-V - blood
Apolipoproteins
Bacterial infections
Biomarkers - blood
Brain
Brain injury
Calcium
Child, Preschool
Children
China
Chromatography, Liquid
Enzyme-linked immunosorbent assay
Enzymes
Fatalities
Fatty acids
Female
Health aspects
Heart rate
Humans
Infant
Infection
Infections
Inflammation
Injuries
Intensive Care Units, Pediatric - statistics & numerical data
Kidneys
Laboratories
Lipid metabolism
Lipids
Lipopolysaccharides
Lipopolysaccharides - blood
Liver
Male
Mass spectrometry
Medical prognosis
Medical research
Medicine, Experimental
Metabolism
Mitogens
Mortality
Pathogens
Patients
Pediatric intensive care
Pediatrics
Physiological aspects
Pilot Projects
Population
Prospective Studies
Proteomics
Respiratory failure
ROC Curve
Scientific imaging
Sepsis
Sepsis - blood
Serum levels
Shock
Taiwan
Ventilators
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Summary:Background. Sepsis induces the release of lipid mediators, which control both lipid metabolism and inflammation. However, the role of serum apolipoprotein A-V (ApoA5) in sepsis is poorly understood in pediatric patients. Methods. ApoA5 was screened from serum proteomics profile in lipopolysaccharide- (LPS-) treated mice for 2 h, 24 h, and controls. Then, we conducted a prospective pilot study, and patients with sepsis admitted to a pediatric intensive care unit (PICU) were enrolled from January 2018 to December 2018. Serum ApoA5 levels on PICU admission were determined using enzyme-linked immunosorbent assays (ELISA). Blood samples from 30 healthy children were used as control. The correlation of ApoA5 with the clinical and laboratory parameters was analyzed. Logistic regression analyses and receiver operating characteristic curve (ROC) analysis were used to investigate the potential role of serum ApoA5 as a prognostic predictor for PICU mortality in pediatric patients with sepsis. Results. A total of 101 patients with sepsis were enrolled in this study. The PICU mortality rate was 10.9% (11/101). Serum ApoA5 levels on PICU admission were significantly lower in nonsurvivors with sepsis compared with survivors (P=0.009). In subgroup analysis, serum levels of ApoA5 were significantly correlated with sepsis-associated multiple organ dysfunction syndrome (MODS) (P
ISSN:0962-9351
1466-1861
DOI:10.1155/2020/8052954