Association of YKL-40 with endothelial dysfunction in patients with essential hypertension

Human cartilage glycoprotein 39 (YKL-40) is related with presence and extent of atherosclerosis, which can be a new biomarker of inflammation and endothelial dysfunction. The relationship between YKL-40 and endothelial dysfunction in patients with essential hypertension (EH) has not been intensively...

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Bibliographic Details
Published in:European journal of inflammation 2020-09, Vol.18, p.205873922095993
Main Authors: Ji, Qing-hong, Zhao, Meng-meng, Gong, Hui-ping, Lv, Xian-zhong, Ma, Wei-hong
Format: Article
Language:English
Subjects:
Hypertension
Nitric oxide
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Summary:Human cartilage glycoprotein 39 (YKL-40) is related with presence and extent of atherosclerosis, which can be a new biomarker of inflammation and endothelial dysfunction. The relationship between YKL-40 and endothelial dysfunction in patients with essential hypertension (EH) has not been intensively investigated. The relationship between serum level of YKL-40 and endothelial dysfunction was evaluated in 60 EH subjects and 50 normal control (NEH) subjects. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of YKL-40. Brachial artery flow-mediated vasodilation (FMD) was used to measure endothelial-dependent nitric oxide-mediated vasodilatory capacity as the function of endothelial index. This study demonstrated that YKL-40 expression was significantly increased (p 
ISSN:1721-727X
2058-7392
2058-7392
DOI:10.1177/2058739220959939