Expression of microRNA-27b in type 2 diabetic patients and relation to microvascular complications

• Published in: Alexandria journal of medicine 2024-12, Vol.60 (1), p.336-341
• Main Authors: Ghanem, Yehia Mostafa, Moursy, Eman Youssef, Elsayed, Eman Tayae, El Sayed, Norhan Yousri, Mahmoud, Reem Fathallah
• Format: Article
• Language: English
• Subjects: Diabetes; kidney disease; neuropathy; retinopathy
• ISSN: 2090-5068; 2090-5076
• DOI: 10.1080/20905068.2024.2398965

In this study, we aimed to explore whether circulating microRNA-27b (miR-27b) is affected in diabetic patient with microvascular complicationsMethods This study was conducted on 90 participants, 30 had type 2 diabetes with chronic limb ischemia, 30 diabetics without chronic limb ischemia and 30 healthy controls. The relative expression of microRNA 27b was assessed in the patient groups and its relation between diabetic retinopathy (DR), diabetic kidney disease (DKD), and diabetic neuropathy (DN).Results Concerning relation between miR-27b and other microvascular complications, DR & DN, miR-27b plasma expression showed no significant difference between T2DM patients with increased VPT compared to those with normal VPT. Comparably, there was no significant difference in the plasma miR-27b expression between patients with DR and those with normal fundus examination. Additionally, neither DR nor VPT correlated with plasma miR-27bexpression.Conclusion Plasma miR-27b expression showed no change between the patient groups and there was no correlation with microvascular complications and miR-27b expression.