Systematic Influence of Circulating Bilirubin Levels on Osteoporosis

Observational studies report some association between circulating bilirubin levels and osteoporosis, but it is unknown if this association is causal or confounded. In this two-sample Mendelian randomization (MR) study, we included a large genome-wide association study (GWAS) associated with total bi...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2021-08, Vol.12, p.719920-719920
Main Authors: Zhao, Jinqiu, Zhang, Muzi, Quan, Zhengxue, Deng, Liang, Li, Yongguo, He, Bin
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bilirubin - blood
BMD
Bone Density - genetics
Causality
circulating bilirubin levels
Endocrinology
Female
fracture
Fractures, Bone - blood
Fractures, Bone - epidemiology
Fractures, Bone - genetics
Genome-Wide Association Study
Humans
Male
Mendelian Randomization Analysis
Mendelian randomization study
Middle Aged
osteoporosis
Osteoporosis - blood
Osteoporosis - epidemiology
Osteoporosis - genetics
Polymorphism, Single Nucleotide
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Observational studies report some association between circulating bilirubin levels and osteoporosis, but it is unknown if this association is causal or confounded. In this two-sample Mendelian randomization (MR) study, we included a large genome-wide association study (GWAS) associated with total bilirubin levels among 317,639 people, a large meta-analysis to identify genetic variants associated with bone mineral density (BMD) estimated by heel quantitative ultrasound (eBMD) among 426,824 individuals and fracture among 1.2 million individuals. The results revealed that circulating bilirubin levels had no causal influence on eBMD (beta-estimate: 0.004, 95% confidence interval [CI]: -0.019 to 0.028, SE:0.012, P-value=0.705) or the risk of fracture (beta-estimate: -0.009, 95% CI: -0.035 to 0.017, SE:0.013, P-value=0.488), which were both confirmed by multiple sensitivity analyses. Our results confirm that circulating bilirubin levels have no causal role in eBMD or the incidence of fracture, indicating that circulating bilirubin levels is unlikely to be a causal risk factor for osteoporosis or fracture.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2021.719920