Maternal ingestion of cocoa causes constriction of fetal ductus arteriosus in rats

Maternal consumption of polyphenol-rich foods has been associated with fetal ductus arteriosus constriction (DAC), but safety of chocolate exposure in fetal life has not been studied. This experimental study tested the hypothesis that maternal cocoa consumption in late pregnancy causes fetal DAC, wi...

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Published in:Scientific reports 2021-05, Vol.11 (1), p.9929-9929, Article 9929
Main Authors: Zielinsky, Paulo, Martignoni, Felipe Villa, Markoski, Melissa, Zucatti, Kelly Pozzer, dos Santos Marinho, Gabriela, Pozzobon, Gabriela, Magno, Pedro Rafael, de Bittencourt Antunes, Victória, Sulis, Natassia Miranda, Cardoso, Alexandra, Mattos, Daniel, Naujorks, Alexandre Antônio, von Frankenberg, Anize Delfino, Vian, Izabele
Format: Article
Language:English
Subjects:
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692/308
692/4019
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Antioxidants
Chocolate
Cocoa
Fetuses
Food consumption
Gestation
Humanities and Social Sciences
Hypertension
Indomethacin
Ingestion
multidisciplinary
Pregnancy
Pulmonary arteries
Pulmonary artery
Science
Science (multidisciplinary)
Statistical analysis
Thiobarbituric acid
Variance analysis
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Summary:Maternal consumption of polyphenol-rich foods has been associated with fetal ductus arteriosus constriction (DAC), but safety of chocolate exposure in fetal life has not been studied. This experimental study tested the hypothesis that maternal cocoa consumption in late pregnancy causes fetal DAC, with possible associated antioxidant effects. Pregnant Wistar rats, at the 21st gestational day, received by orogastric tube cocoa (720 mg/Kg) for 12 h, indomethacin (10 mg/Kg), for 8 h, or only water, before cesaren section. Immediately after withdrawal, every thorax was obtained and tissues were fixed and stained for histological analysis. The ratio of the narrowest part of the pulmonary artery to the fetal ductus inner diameter and increased ductal inner wall thickness characterized ductal constriction. Substances reactive to thiobarbituric acid were quantified. Statistical analysis used ANOVA and Tukey test. Cocoa (n = 33) and indomethacin (n = 7) reduced fetal internal ductus diameter when compared to control (water, n = 25) (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-89309-x