Upconversion-Powered Photoelectrochemical Bioanalysis for DNA Sensing

In this work, we report a new concept of upconversion-powered photoelectrochemical (PEC) bioanalysis. The proof-of-concept involves a PEC bionanosystem comprising a NaYF :Yb,Tm@NaYF upconversion nanoparticles (UCNPs) reporter, which is confined by DNA hybridization on a CdS quantum dots (QDs)/indium...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2024-01, Vol.24 (3), p.773
Main Authors: Liu, Hong, Wei, Weiwei, Song, Jiajun, Hu, Jin, Wang, Zhezhe, Lin, Peng
Format: Article
Language:English
Subjects:
Biomarkers
Biosensing Techniques
Biosensors
DNA
DNA - analysis
Electrochemical Techniques
Electrodes
Energy
energy transfer
Hybridization
Indium
Indium tin oxides
Light
Limit of Detection
Nanoparticles
Nucleic Acid Hybridization
photo reabsorption
photoelectrochemical biosensors
Polyethylene glycol
Quantum Dots
Semiconductors
Signal transduction
upconversion nanoparticles
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Summary:In this work, we report a new concept of upconversion-powered photoelectrochemical (PEC) bioanalysis. The proof-of-concept involves a PEC bionanosystem comprising a NaYF :Yb,Tm@NaYF upconversion nanoparticles (UCNPs) reporter, which is confined by DNA hybridization on a CdS quantum dots (QDs)/indium tin oxide (ITO) photoelectrode. The CdS QD-modified ITO electrode was powered by upconversion absorption together with energy transfer effect through UCNPs for a stable photocurrent generation. By measuring the photocurrent change, the target DNA could be detected in a specific and sensitive way with a wide linear range from 10 pM to 1 μM and a low detection limit of 0.1 pM. This work exploited the use of UCNPs as signal reporters and realized upconversion-powered PEC bioanalysis. Given the diversity of UCNPs, we believe it will offer a new perspective for the development of advanced upconversion-powered PEC bioanalysis.
ISSN:1424-8220
1424-8220
DOI:10.3390/s24030773