Review on Pediatric Malignant Focal Liver Lesions with Imaging Evaluation: Part I

Malignant focal liver lesions (FLLs) are commonly reported in adults but rarely seen in the pediatric population. Due to the rarity, the understanding of these diseases is still very limited. In children, most malignant FLLs are congenital. It is very important to choose appropriate imaging examinat...

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Bibliographic Details
Published in:Diagnostics (Basel) 2023-11, Vol.13 (23), p.3568
Main Authors: Dong, Yi, Cekuolis, Andrius, Schreiber-Dietrich, Dagmar, Augustiniene, Rasa, Schwarz, Simone, Möller, Kathleen, Nourkami-Tutdibi, Nasenien, Chen, Sheng, Cao, Jia-Ying, Huang, Yun-Lin, Wang, Ying, Taut, Heike, Grevelding, Lara, Dietrich, Christoph F
Format: Article
Language:English
Subjects:
Age
Anesthesia
Care and treatment
Children
Contrast agents
contrast enhanced ultrasound (CEUS)
Diagnosis
FDA approval
focal liver lesions (FLLs)
Genetic disorders
Health aspects
imaging
Liver
Liver cancer
Localization
Magnetic resonance imaging
malignant
Medical imaging equipment
Metastasis
pediatric
Pediatrics
Radiation
Tomography
Tumors
Ultrasonic imaging
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Summary:Malignant focal liver lesions (FLLs) are commonly reported in adults but rarely seen in the pediatric population. Due to the rarity, the understanding of these diseases is still very limited. In children, most malignant FLLs are congenital. It is very important to choose appropriate imaging examination concerning various factors. This paper will outline common pediatric malignant FLLs, including hepatoblastoma, hepatocellular carcinoma, and cholangiocarcinoma and discuss them against the background of the latest knowledge on comparable/similar tumors in adults. Medical imaging features are of vital importance for the non-invasive diagnosis and follow-up of treatment of FLLs in pediatric patients. The use of CEUS in pediatric patients for characterizing those FLLs that remain indeterminate on conventional B mode ultrasounds may be an effective option in the future and has great potential to be integrated into imaging algorithms without the risk of exposure to ionizing radiation.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13233568