Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-07, Vol.21 (14), p.4915
Main Author: Choi, Bu Young
Format: Article
Language:English
Subjects:
Alopecia
Alopecia - drug therapy
Alopecia - metabolism
Alopecia - therapy
Animals
Antifungal agents
Baldness
Biological Products - pharmacology
Biological Products - therapeutic use
Combined Modality Therapy
Female
Fungal infections
Growth factors
Hair
Hair - growth & development
Hair Follicle - drug effects
Hair Follicle - physiology
Hair loss
Hair Preparations - pharmacology
Hair Preparations - therapeutic use
Humans
In vivo methods and tests
Kinases
Male
Mesenchymal Stem Cell Transplantation
Mice
Mice, Nude
Molecular Targeted Therapy
Morphogenesis
Pathophysiology
Phosphorylation
Phytotherapy
Plants
Proteins
Quality of life
Regeneration - drug effects
Review
Signal transduction
Stem cells
Wnt protein
Wnt Signaling Pathway - drug effects
Wnt/β-catenin signaling
β-Catenin
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Summary:Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/β-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activating Wnt/β-catenin signaling in various in vitro and in vivo studies. This mini-review sheds light on the role of Wnt/β-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21144915