A study on isolation, identification, and antifungal susceptibility of various oral candidal species in renal transplant patients

Background: The rationale of this study was to know the prevalence of candidal colonization in renal transplant individuals and to isolate and identify the various species and determine their antifungal susceptibility. Materials and Methods: The study population was divided into Group I (renal trans...

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Published in:Journal of Dr. NTR university of health sciences 2015-07, Vol.4 (3), p.170-175
Main Authors: Keerthi, Muddana, Reddy, Gontu, Shekar, Poosarla, Chandra, Kantheti, Kumar, Kattapagari, Reddy, Baddam
Format: Article
Language:English
Subjects:
Candida
Candida albicans
Health aspects
Identification and classification
immunosuppressive drugs
Kidney transplantation
Medical research
Microbial sensitivity tests
oral candidiasis
Organ transplant recipients
Physiological aspects
renal transplants
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Summary:Background: The rationale of this study was to know the prevalence of candidal colonization in renal transplant individuals and to isolate and identify the various species and determine their antifungal susceptibility. Materials and Methods: The study population was divided into Group I (renal transplant individuals, n =30) and Group II (healthy individuals, n =50) from whom oral rinse samples were collected in a container with sterile phosphate-buffered saline (PBS). All the collected samples were transported immediately and subjected to various mycological investigations. Statistical analysis was performed using Mann-Whitney U and Chi-square test. Results: In Group I, 11 (36.67%) and in Group II, 9 (18%) showed positivity for Candida. Candida albicans formed the major species and it showed sensitivity to Fluconazole and Ketoconazole. Conclusion: Prevalence of Candida species in the oral cavity of renal transplant recipients was higher than in immunocompetent control subjects. Administration of immunosuppressive drugs predisposes the development of an increased density of candidal colonies.
ISSN:2277-8632
2277-8632
DOI:10.4103/2277-8632.165399