Antimicrobial and cytotoxic assessment of marine cyanobacteria - Synechocystis and Synechococcus

Aqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the...

Full description

Saved in:
Bibliographic Details
Published in:Marine drugs 2008-01, Vol.6 (1), p.1-11
Main Authors: Martins, R F, Ramos, M F, Herfindal, L, Sousa, J A, Skaerven, K, Vasconcelos, V M
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Antibiotic
Antifungal Agents - metabolism
Antifungal Agents - pharmacology
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Bacteria - drug effects
Candida albicans
Candida albicans - drug effects
Cells, Cultured
Cellulomonas
Clavibacter michiganensis
Cyanobacteria
Cyanophyta
Cytotoxic
Full Original Paper
Humans
Marine
Marine Cyanobacteria
Synechococcus
Synechococcus - metabolism
Synechocystis
Synechocystis - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the agar diffusion assay. Cytotoxic activity was measured by apoptotic cell death scored by cell surface evaluation and nuclear morphology. A high percentage of apoptotic cells were observed for HL-60 cells when treated with cyanobacterial organic extracts. Slight apoptotic effects were observed in primary rat hepatocytes when exposed to aqueous cyanobacterial extracts. Nine cyanobacteria strains were found to have antibiotic activity against two Gram-positive bacteria, Clavibacter michiganensis subsp. insidiosum and Cellulomonas uda. No inhibitory effects were found against the fungus Candida albicans and Gram-negative bacteria. Marine Synechocystis and Synechococcus extracts induce apoptosis in eukaryotic cells and cause inhibition of Gram-positive bacteria. The different activity in different extracts suggests different compounds with different polarities.
ISSN:1660-3397
1660-3397
DOI:10.3390/md6010001