Magnetic Targeting of Magneto-Plasmonic Nanoparticles and Their Effects on Temperature Profile of NIR Laser Irradiated to CT26 Tumor in BALB/C Mice

• Published in: Journal of biomedical physics and engineering 2021-06, Vol.11 (3), p.281-288
• Main Authors: Abed, Ziaeddin, Shakeri-Zadeh, Ali, Eyvazzadeh, Nazila
• Format: Article
• Language: English
• Subjects: cancer; hyperthermia; laser therapy; nanomedicine; nanoparticles; Original
• ISSN: 2251-7200; 2251-7200
• DOI: 10.31661/JBPE.V0I0.1032

Photothermal therapy (PTT) is a promising method in the field of cancer hyperthermia. In this method, interaction between laser light and photosensitizer material, such as plasmonic nanoparticles, leads into a localized heating. Recent efforts in the area of PTT aim to exploit targeting strategies for preferential accumulation of plasmonic nanoparticles within the tumor. To investigate the impact of magneto-plasmonic (Au@Fe O ) nanoparticles on temperature profile of CT26 tumor, bearing mice were irradiated by NIR laser. In this in vivo study, Au@Fe O NPs were injected intraperitoneally to Balb/c mice bearing CT26 colorectal tumor. Immediately after injection, a magnet (magnetic field strength of 0.4 Tesla) was placed on the tumor site for 6 hours in order to concentrate nanoparticles inside the tumor. In the next step, the tumors were exposed with NIR laser source (808 nm; 2 W/cm ; 5 min). Tumor temperature without magnetic targeting increased ~7 ± 0.9 °C after NIR irradiation, whereas the tumors in magnetic targeted group experienced a temperature rise of ~12 ± 1.4 °C. It is concluded that Au@Fe O nanoparticle is a good candidate for therapeutic nanostructure in cancer photothermal therapy.