The new world of RNA diagnostics and therapeutics

The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27-28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled "The New World of RNA diagnostics and therapeutics" highlightes the significant progress in the RNA field made over the last yea...

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Published in:Journal of experimental & clinical cancer research 2023-07, Vol.42 (1), p.189-16, Article 189
Main Authors: Blandino, Giovanni, Dinami, Roberto, Marcia, Marco, Anastasiadou, Eleni, Ryan, Brid M, Palcau, Alina Catalina, Fattore, Luigi, Regazzo, Giulia, Sestito, Rosanna, Loria, Rossella, Díaz Méndez, Ana Belén, Cappelletto, Maria Chiara, Pulito, Claudio, Monteonofrio, Laura, Calin, George A, Sozzi, Gabriella, Cheong, Jit Kong, Aharonov, Ranit, Ciliberto, Gennaro
Format: Article
Language:English
Subjects:
Antibodies
Biomarkers
Breast cancer
Cell cycle
Cell cycle regulation
Cytotoxicity
Epigenetic inheritance
Epigenetics
Epstein-Barr virus
Gene expression
Health aspects
Homeopathy
Humans
Immunotherapy
Italy
Lymphocytes
Lymphoma
Materia medica and therapeutics
Medical Oncology
Meeting Report
Metastasis
MicroRNAs
Mutation
Nanoparticles
Neoplasms - diagnosis
Neoplasms - genetics
Neoplasms - therapy
Precision Medicine
Proteins
RNA
RNA evolution
RNA structure
Splicing
Therapeutics
Transcription factors
Tumors
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Summary:The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27-28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled "The New World of RNA diagnostics and therapeutics" highlightes the significant progress in the RNA field made over the last years. Research moved from pure discovery towards the development of diagnostic biomarkers or RNA-base targeted therapies seeking validation in several clinical trials. Non-coding RNAs in particular have been the focus of this workshop due to their unique properties that make them attractive tools for the diagnosis and therapy of cancer.This report collected the presentations of many scientists from different institutions that discussed recent oncology research providing an excellent overview and representative examples for each possible application of RNA as biomarker, for therapy or to increase the number of patients that can benefit from precision oncology treatment.In particular, the meeting specifically emphasized two key features of RNA applications: RNA diagnostic (Blandino, Palcau, Sestito, Díaz Méndez, Cappelletto, Pulito, Monteonofrio, Calin, Sozzi, Cheong) and RNA therapeutics (Dinami, Marcia, Anastasiadou, Ryan, Fattore, Regazzo, Loria, Aharonov).
ISSN:1756-9966
0392-9078
1756-9966
DOI:10.1186/s13046-023-02752-8