Lipid-based nanoparticles for treatment of cancer

• Published in: Heliyon 2022-05, Vol.8 (5), p.e09403, Article e09403
• Main Authors: Sheoran, Sumit, Arora, Swati, Samsonraj, R., Govindaiah, Pilli, vuree, Sugunakar
• Format: Article
• Language: English
• Subjects: Clinical trials; Lipid based Nanopartcles; Liposomes; Review; Solid lipid nanoparticles; Tumour
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2022.e09403

Investigators were continuously creating novel nanotechnologies to address unmet requirements throughout the administration of therapeutic medicines & imaging agents for cancer treatment & diagnostics, appropriately. LNPs(Lipid nanoparticles) are legitimate particulates (approx. 100 nm in size) gathered from various lipid as well as other biochemical compounds which overall functionality to resolve biological barriers (biobarriers), allowing LNPs to selectively collect somewhere outside of disease-target cells again for responsive therapeutics. Most pharmaceutically important compounds were insoluble throughout water solutions, were chemical & physiologically unstable, or have toxicities. Among the most potential drug carrier for bioactive organic compounds is LBNPs (Lipid based nanoparticles) technologies. Its present use in chemotherapy have transformed treatment for cancer by increasing the antitumor effect of a number of chemotherapeutics. Because they may be created using naturally occurring sources, LBNPs have great temporal and thermal stability, maximum load potential, simplicity of preparations, cheap manufacturing costs, & big manufacturing output. Furthermore, combining chemotherapeutic drugs with LNPs reduces active therapeutic dosage and toxicities, lowers treatment resistance, & raises drug concentration in tumour cells while reducing concentrations in normal tissue. LBNPs were widely studied in cancer treatment, both in vitro and in vivo, with encouraging outcomes in certain clinical trials. This study provides an overview of the many types of LBNPs which have been created in latest years and their applications and contributions in different types of cancers. Lipoid based nanoparticles; Tumour; Clinical trials; Liposomes; Solid lipid nanoparticles.