Detection of thrombus size and protein content by ex vivo magnetization transfer and diffusion weighted MRI

To utilize a rabbit model of plaque disruption to assess the accuracy of different magnetic resonance sequences [T1-weighted (T1W), T2-weighted (T2W), magnetization transfer (MT) and diffusion weighting (DW)] at 11.7 T for the ex vivo detection of size and composition of thrombus associated with dis...

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Bibliographic Details
Published in:Journal of cardiovascular magnetic resonance 2012-06, Vol.14 (1), p.45-45, Article 49
Main Authors: Phinikaridou, Alkystis, Qiao, Ye, Giordano, Nick, Hamilton, James A
Format: Article
Language:English
Subjects:
Animals
Aorta
Aorta, Thoracic - chemistry
Aorta, Thoracic - pathology
Aortic Diseases - diagnosis
Aortic Diseases - metabolism
Atherosclerosis
Blood clot
Blood clots
Cholesterol
Contrast agents
Diagnosis
Diagnosis, Differential
Diffusion
Diffusion Magnetic Resonance Imaging - methods
Disruption
Fibrin
Formaldehyde
Heart attacks
Histology
Image contrast
Magnetic resonance
Magnetic resonance imaging
Magnetization
Male
Plaque, Atherosclerotic - chemistry
Plaque, Atherosclerotic - complications
Plaque, Atherosclerotic - pathology
Proteins - analysis
Rabbits
Reproducibility of Results
Studies
Thrombosis
Thrombosis - diagnosis
Thrombosis - etiology
Thrombosis - metabolism
Veins & arteries
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Summary:To utilize a rabbit model of plaque disruption to assess the accuracy of different magnetic resonance sequences [T1-weighted (T1W), T2-weighted (T2W), magnetization transfer (MT) and diffusion weighting (DW)] at 11.7 T for the ex vivo detection of size and composition of thrombus associated with disrupted plaques. Atherosclerosis was induced in the aorta of male New Zealand White rabbits (n = 17) by endothelial denudation and high-cholesterol diet. Subsequently, plaque disruption was induced by pharmacological triggering. Segments of infra-renal aorta were excised fixed in formalin and examined by ex vivo magnetic resonance imaging (MRI) at 11.7 T and histology. MRI at 11.7 T showed that: (i) magnetization transfer contrast (MTC) and diffusion weighted images (DWI) detected thrombus with higher sensitivity compared to T1W and T2W images [sensitivity: MTC = 88.2%, DWI = 76.5%, T1W = 66.6% and T2W = 43.7%, P 
ISSN:1097-6647
1532-429X
1532-429X
DOI:10.1186/1532-429X-14-45