Association between single nucleotide variants and severe chronic pain in older adult patients after lower extremity arthroplasty

• Published in: Journal of orthopaedic surgery and research 2023-03, Vol.18 (1), p.184-9, Article 184
• Main Authors: Xu, Rui, Jin, Yinan, Tang, Suhong, Wang, Wenwen, Sun, Yu-E, Liu, Yue, Zhang, Wei, Hou, Bailing, Huang, Yulin, Ma, Zhengliang
• Format: Article
• Language: English
• Subjects: Aged; Aged patients; Amino acids; Arthritis; Arthroplasty; Arthroplasty (hip); Arthroplasty (knee); Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Biotechnology industry; Cell adhesion; Chromatin; Chromatin remodeling; Chronic pain; Chronic Pain - genetics; Chronic Pain - surgery; Chronic postsurgical pain; Cytochrome P-450; DNA methylation; Extracellular matrix; Genes; Genomes; Humans; Joint replacement surgery; Knee; Medical colleges; Methylation; Narcotics; Normal distribution; Nucleotides; Older adult; Older people; Ontology; Orthopedics; Osteoarthritis; Osteoarthritis, Hip - surgery; Osteoarthritis, Knee - complications; Osteoarthritis, Knee - genetics; Osteoarthritis, Knee - surgery; Pain, Postoperative - genetics; Patients; Physiological aspects; Polymorphism; Population genetics; Prognosis; Quality control; ras Guanine Nucleotide Exchange Factors; Regression analysis; Single nucleotide variants; Software; Statistical analysis; Treatment Outcome
• ISSN: 1749-799X; 1749-799X
• DOI: 10.1186/s13018-023-03683-y

Hip or knee osteoarthritis (OA) is one of the main causes of disability worldwide and occurs mostly in the older adults. Total hip or knee arthroplasty is the most effective method to treat OA. However, severe postsurgical pain leading to a poor prognosis. So, investigating the population genetics and genes related to severe chronic pain in older adult patients after lower extremity arthroplasty is helpful to improve the quality of treatment. We collected blood samples from elderly patients who underwent lower extremity arthroplasty from September 2020 to February 2021 at the Drum Tower Hospital Affiliated to Nanjing University Medical School. The enrolled patients provided measures of pain intensity using the numerical rating scale on the 90th day after surgery. Patients were divided into the case group (Group A) and the control group (Group B) including 10 patients respectively by the numerical rating scale. DNA was isolated from the blood samples of the two groups for whole-exome sequencing. In total, 661 variants were identified in the 507 gene regions that were significantly different between both groups (P