Rifampin- and multidrug-resistant tuberculosis in Russian civilians and prison inmates: dominance of the beijing strain family

Consecutive patient cultures (140) of Mycobacteriium tuberculosis were collected from five Russian civilian and prison tuberculosis laboratories and analyzed for rifampin (rpoB) and isoniazid resistance (inhA, katG, ahpC); transmission of Beijing family isolates; and the importance of prison and pre...

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Published in:Emerging infectious diseases 2002-11, Vol.8 (11), p.1320-1326
Main Authors: Drobniewski, Francis, Balabanova, Yanina, Ruddy, Michael, Weldon, Laura, Jeltkova, Katya, Brown, Timothy, Malomanova, Nadezdna, Elizarova, Elvira, Melentyey, Alexander, Mutovkin, Ebgeny, Zhakharova, Svetlana, Fedorin, Ivan
Format: Article
Language:English
Subjects:
Antitubercular Agents - pharmacology
Antitubercular Agents - therapeutic use
China
Drug resistance
Drug Resistance, Multiple, Bacterial
Female
Health aspects
Humans
Isoniazid
Male
Minisatellite Repeats
Mutation
Mycobacteria
Mycobacterium tuberculosis - classification
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Prisoners
Rifampin
Rifampin - pharmacology
Rifampin - therapeutic use
Russia
Russia - epidemiology
Tuberculosis
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis - microbiology
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Summary:Consecutive patient cultures (140) of Mycobacteriium tuberculosis were collected from five Russian civilian and prison tuberculosis laboratories and analyzed for rifampin (rpoB) and isoniazid resistance (inhA, katG, ahpC); transmission of Beijing family isolates; and the importance of prison and previous therapy in drug resistance. Rifampin, isoniazid, and multidrug resistance occurred in 58.2%, 51.6%, and 44.7% of cultures, respectively; 80% of prison cultures were rifampin resistant. Spoligotyping and variable number tandem repeat (VNTR) fingerprinting divided the isolates into 43 groups. Spoligotyping demonstrated that a high proportion (68.1%) of patients were infected with Beijing family strains and that most (69.1%) were rifampin resistant; the highest proportion (81.6%) occurred in prison. One VNTR subgroup (42435) comprised 68 (72.3%) of the Beijing isolates with a small number of IS6110 types; 50 (73.5%) were rifampin resistant. Rifampin-resistant Beijing isolates are dominant within the patient population, especially among prisoners, and threaten treatment programs.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid0811.020507