Association of MCP-1 -2518 A/G Single Nucleotide Polymorphism with the Serum Level of CRP in Slovak Patients with Ischemic Heart Disease, Angina Pectoris, and Hypertension

The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) an...

Full description

Saved in:
Bibliographic Details
Published in:Mediators of Inflammation 2009-01, Vol.2009 (2009), p.203-208
Main Authors: Lietava, Jan, Mrazek, Frantisek, Bucova, Maria, Petrek, Martin, Bernadic, Marian, Petrkova, Jana, Penz, Peter
Format: Article
Language:English
Subjects:
Aged
Angina Pectoris - blood
Angina Pectoris - genetics
C-Reactive Protein - metabolism
Cardiac patients
Chemokine CCL2 - genetics
Chemokines
Clinical Study
Female
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease - genetics
Humans
Hypertension - blood
Hypertension - genetics
Male
Middle Aged
Myocardial Ischemia - blood
Myocardial Ischemia - genetics
Physiological aspects
Polymorphism, Single Nucleotide - genetics
Slovakia
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group of healthy subjects. Totally, 263 patients with the diagnosis of IHD, out of them 89 with MI, 145 with AP, 205 with HT, and also 67 healthy subjects were included in the study. First, we estimated the serum levels of hsCRP. We found that patients with AP had significantly higher serum level of hsCRP than both control group of healthy subjects (P=.043) and IHD patients without AP (P=.026). The presence of the mutant G allele statistically significantly correlated with the higher serum levels of hsCRP in patients with IHD (P=.016), AP (P=.004), and HT (P=.013). Higher correlations were found in men (AP: P=.019; HT: P=.047). In all cases the highest levels of hsCRP were found both in patients and healthy controls with homozygous GG genotype.
ISSN:0962-9351
1466-1861
DOI:10.1155/2009/390951