Blood serum proteins as biomarkers for prediction of survival, locoregional control and distant metastasis rate in radiotherapy and radio-chemotherapy for non-small cell lung cancer

Several studies have documented that blood biomarkers can improve basic prognostic models in radiotherapy and radio-chemotherapy for non-small cell lung cancer. The current study evaluated the prognostic impact of six markers focusing on their utility in homogenous subsets, compared to the significa...

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Bibliographic Details
Published in:BMC cancer 2019-05, Vol.19 (1), p.427-12, Article 427
Main Authors: Suwinski, Rafał, Giglok, Monika, Galwas-Kliber, Katarzyna, Idasiak, Adam, Jochymek, Bozena, Deja, Regina, Maslyk, Barbara, Mrochem-Kwarciak, Jolanta, Butkiewicz, Dorota
Format: Article
Language:English
Subjects:
Biological markers
Biological products
Biomarkers
Blood proteins
Cancer metastasis
Cancer research
Cancer therapies
Cancer treatment
Care and treatment
Chemotherapy
Chromosomal proteins
Cigarette smoking
Endothelial growth factors
Endothelium
Enzyme-linked immunosorbent assay
Erythropoietin
Gene expression
High mobility group proteins
Histology
HMGB1 protein
Insulin
Insulin-like growth factor I
Insulin-like growth factors
Lung cancer
Medical prognosis
Metastases
Mutation
Non-small cell lung cancer
Non-small cell lung carcinoma
Osteopontin
Platelet-derived growth factor
Prognosis
Proteins
Radiation therapy
Radiotherapy
Serum proteins
Small cell lung cancer
Smoking
Studies
Surgery
Survival
Thorax
Tumors
Vascular endothelial growth factor
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Summary:Several studies have documented that blood biomarkers can improve basic prognostic models in radiotherapy and radio-chemotherapy for non-small cell lung cancer. The current study evaluated the prognostic impact of six markers focusing on their utility in homogenous subsets, compared to the significance in a large heterogeneous group. Blood samples of 337 patients who were referred for curative or palliative external beam thoracic radiotherapy for non-small cell lung cancer were collected. The concentration of osteopontin (OPN), vascular endothelial growth factor (VEGF), erythropoetin (EPO), high mobility group box 1 protein (HMGB1), insulin-like growth factor 1 (IGF-1) and platelet-derived growth factor (PDGF) in serum were measured by ELISA assay and the prognostic potential was assessed using univariable and multivariable survival models. Multivariable analysis revealed that out of several variables studied six dichotomized features: namely: cigarette smoking, lack of chemotherapy, palliative doses of radiotherapy, high OPN concentration, advanced T stage and high VEGF concentration had a highly significant (p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-019-5617-1