Development of an efficient electrochemical sensor based on CuAl-LDH using an electrostatic repulsion approach for the selective determination of dopamine in the presence of uric acid and ascorbic acid species

• Published in: Electrochemistry communications 2024-08, Vol.165, p.107756, Article 107756
• Main Authors: Shahparast, Saeedeh, Asadpour-Zeynali, Karim
• Format: Article
• Language: English
• Subjects: CuAl-LDH/GCE; Differential pulse voltammetry; Electrochemical sensor; Human plasma; Selective determination of dopamine
• ISSN: 1388-2481; 1873-1902
• DOI: 10.1016/j.elecom.2024.107756

[Display omitted] •A new, highly sensitive and selective sensor based on CuAl-LDH has been developed for electrochemical determination of dopamine.•A one-step coprecipitation method was used to prepare Cu-Al layered double hydroxide composites.•The propsed sensor indicated wide linear range (4.194–1151.54 μM) and low detection limit (0.33 μM).•Dopamine in pharmaceutical ampoules and plasma samples was measured satisfactorily using this sensor. This study provides a unique electrochemical sensor that exhibits both excellent sensitivity and selectivity, while also being environmentally friendly. The CuAl-LDH/GCE sensor, proposed as the recommended sensor, was synthesized using a straightforward one-step co-precipitation procedure. It was first used to measure dopamine levels using differential pulse voltammetry. At the ideal pH level of 8, dopamine has a positive charge, but ascorbic acid and uric acid have a negative charge. LDH, on the other hand, carries a negative charge and exhibits high electrostatic attraction towards dopamine, but is electrostatically repelled by negatively charged ascorbic acid and uric acid. Hence, CuAl-LDH/GCE has the potential to specifically ascertain the existence of dopamine in the presence of these particular species. The examination of the composition and morphology of CuAl-LDH was conducted using various analytical techniques, including scanner electron microscopy (FESEM), transmission electron microscope (TEM), element mapping (MAP), Fourier transform infrared (FTIR), energy-dispersive X-ray spectroscopy (EDX), Brunauer Emmett Teller (BET), X-ray photoelectron diffraction (XRD), and Raman techniques. Under ideal circumstances, the calibration graph of dopamine was generated using differential pulse voltammetry. A linear range of 4.194–1151.54 μM was achieved for dopamine, with a limit of detection of 0.33 μM. The findings of the study indicate that the sensor created for dopamine determination has exceptional stability, repeatability, and reproducibility. The sensor that was presented was effectively used for the measurement of dopamine in both pharmaceutical ampoules and human plasma samples.